2022年

3D imaging of supraspinal inputs to the thoracic and lumbar spinal cord mapped by retrograde tracing and light-sheet microscopy.
Lu T, Shinozaki M, Nagoshi N, Nakamura M, Okano H.
J Neurochem. 2022 Jun 8. doi: 10.1111/jnc.15653. Online ahead of print.
PMID: 35674500

The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests.
Inagaki E, Arai E, Hatou S, Sayano T, Taniguchi H, Negishi K, Kanai Y, Sato Y, Okano H, Tsubota K, Shimmura S.
Stem Cells Transl Med. 2022 Jun 6:szac036. doi: 10.1093/stcltm/szac036. Online ahead of print.
PMID: 35666752

Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD.
Imaizumi K, Ideno H, Sato T, Morimoto S, Okano H.
eNeuro. 2022 Jun 8;9(3):ENEURO.0061-22.2022. doi: 10.1523/ENEURO.0061-22.2022. Print 2022 May-Jun.
PMID: 35641224

TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Morimoto Y, Tokumitsu A, Sone T, Hirota Y, Tamura R, Sakamoto A, Nakajima K, Toda M, Kawakami Y, Okano H, Ohta S.
Neurochem Res. 2022 May 27. doi: 10.1007/s11064-022-03629-6. Online ahead of print.
PMID: 35622214

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish.
Saeki T, Yoshimatsu S, Ishikawa M, Hon CC, Koya I, Shibata S, Hosoya M, Saegusa C, Ogawa K, Shin JW, Fujioka M, Okano H.
Regen Ther. 2022 May 16;20:165-186. doi: 10.1016/j.reth.2022.04.008. eCollection 2022 Jun.
PMID: 35620640

Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa.
Ozawa Y, Toda E, Homma K, Osada H, Nagai N, Tsubota K, Okano H.
Cells. 2022 Apr 29;11(9):1497. doi: 10.3390/cells11091497.
PMID: 35563803
Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer’s disease (AD) donor with multiple risk SNPs for sporadic Alzheimer’s disease (sAD).
Supakul S, Leventoux N, Tabuchi H, Mimura M, Ito D, Maeda S, Okano H.
Stem Cell Res. 2022 May 5;62:102802. doi: 10.1016/j.scr.2022.102802. Online ahead of print.
PMID: 35537244

Treadmill Training for Common Marmoset to Strengthen Corticospinal Connections After Thoracic Contusion Spinal Cord Injury.
Kondo T, Saito R, Sato Y, Sato K, Uchida A, Yoshino-Saito K, Shinozaki M, Tashiro S, Nagoshi N, Nakamura M, Ushiba J, Okano H.
Front Cell Neurosci. 2022 Apr 22;16:858562. doi: 10.3389/fncel.2022.858562. eCollection 2022.
PMID: 35530175

Early development of the cochlea of the common marmoset, a non-human primate model.
Hosoya M, Fujioka M, Okahara J, Yoshimatsu S, Okano H, Ozawa H.
Neural Dev. 2022 May 7;17(1):6. doi: 10.1186/s13064-022-00162-8.
PMID: 35524278

The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promot- ing microtubule polymerization.
Kase Y, Sato T, Okano Y, Okano H.
iScience 2022 April. link プレスリリース

Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy.
Kurihara S, Fujioka M, Hirabayashi M, Yoshida T, Hosoya M, Nagase M, Kato F, Ogawa K, Okano H, Kojima H, Okano HJ.
Stem Cells Transl Med. 2022 Mar 31;11(3):282-296. doi: 10.1093/stcltm/szab023.
[PubMed]

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice.
Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, Kubota Y.
J Exp Med. 2022 Apr 4;219(4):e20211789. doi: 10.1084/jem.20211789. Epub 2022 Mar 23.
[PubMed]

Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction.
Yanagisawa T, Ouchi T, Shibata S, Negishi T, Okano H.
Biochem Biophys Res Commun. 2022 Mar 3;603:49-56. doi: 10.1016/j.bbrc.2022.03.002. Online ahead of print.
[PubMed]

Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets.
Sato Y, Kondo T, Uchida A, Sato K, Yoshino-Saito K, Nakamura M, Okano H, Ushiba J.
Behav Brain Res. 2022 May 3;425:113816. doi: 10.1016/j.bbr.2022.113816. Epub 2022 Feb 26.
[PubMed]

Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies.
Tashiro S, Nakamura M, Okano H.
Cells. 2022 Feb 16;11(4):685. doi: 10.3390/cells11040685.
[PubMed]

Administration of C5a receptor antagonist improves the efficacy of human iPSCs-derived NS/PC transplantation in the acute phase of spinal cord injury.
Shibata R, Nagoshi N, Kajikawa K, Ito S, Shibata S, Shindo T, Khazaei M, Nori S, Kohyama J, Fehlings MG, Matsumoto M, Nakamura M, Okano H.
J Neurotrauma. 2022 Feb 24. doi: 10.1089/neu.2021.0225. Online ahead of print.
[PubMed]

Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset.
Yoshimatsu S, Nakajima M, Qian E, Sanosaka T, Sato T, Okano H.
Cells. 2022 Jan 21;11(3):360. doi: 10.3390/cells11030360.
[PubMed]

iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders.
Okano H, Morimoto S.
Cell Stem Cell. 2022 Feb 3;29(2):189-208. doi: 10.1016/j.stem.2022.01.007.
[PubMed]
Cortical neural dynamics unveil the rhythm of natural visual behavior in marmosets.
Kaneko T, Komatsu M, Yamamori T, Ichinohe N, Okano H.
Commun Biol. 2022 Feb 3;5(1):108. doi: 10.1038/s42003-022-03052-1.
[PubMed]

Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice.
Imai C, Sano H, Quispe-Salcedo A, Saito K, Nakatomi M, Ida-Yonemochi H, Okano H, Ohshima H.
J Oral Biosci. 2022 Jan 11:S1349-0079(22)00001-9. doi: 10.1016/j.job.2022.01.001. [PubMed]

Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury.
Kitagawa T, Nagoshi N, Kamata Y, Kawai M, Ago K, Kajikawa K, Shibata R, Sato Y, Imaizumi K, Shindo T, Shinozaki M, Kohyama J, Shibata S, Matsumoto M, Nakamura M, Okano H.
Stem Cell Reports. 2022 doi: 10.1016/j.stemcr.2021.12.005.
[PubMed]