2022年

The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promot- ing microtubule polymerization.
Kase Y, Sato T, Okano Y, Okano H.
iScience 2022 April. link プレスリリース

Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy.
Kurihara S, Fujioka M, Hirabayashi M, Yoshida T, Hosoya M, Nagase M, Kato F, Ogawa K, Okano H, Kojima H, Okano HJ.
Stem Cells Transl Med. 2022 Mar 31;11(3):282-296. doi: 10.1093/stcltm/szab023.
[PubMed]

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice.
Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, Kubota Y.
J Exp Med. 2022 Apr 4;219(4):e20211789. doi: 10.1084/jem.20211789. Epub 2022 Mar 23.
[PubMed]

Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction.
Yanagisawa T, Ouchi T, Shibata S, Negishi T, Okano H.
Biochem Biophys Res Commun. 2022 Mar 3;603:49-56. doi: 10.1016/j.bbrc.2022.03.002. Online ahead of print.
[PubMed]

Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets.
Sato Y, Kondo T, Uchida A, Sato K, Yoshino-Saito K, Nakamura M, Okano H, Ushiba J.
Behav Brain Res. 2022 May 3;425:113816. doi: 10.1016/j.bbr.2022.113816. Epub 2022 Feb 26.
[PubMed]

Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies.
Tashiro S, Nakamura M, Okano H.
Cells. 2022 Feb 16;11(4):685. doi: 10.3390/cells11040685.
[PubMed]

Administration of C5a receptor antagonist improves the efficacy of human iPSCs-derived NS/PC transplantation in the acute phase of spinal cord injury.
Shibata R, Nagoshi N, Kajikawa K, Ito S, Shibata S, Shindo T, Khazaei M, Nori S, Kohyama J, Fehlings MG, Matsumoto M, Nakamura M, Okano H.
J Neurotrauma. 2022 Feb 24. doi: 10.1089/neu.2021.0225. Online ahead of print.
[PubMed]

Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset.
Yoshimatsu S, Nakajima M, Qian E, Sanosaka T, Sato T, Okano H.
Cells. 2022 Jan 21;11(3):360. doi: 10.3390/cells11030360.
[PubMed]

iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders.
Okano H, Morimoto S.
Cell Stem Cell. 2022 Feb 3;29(2):189-208. doi: 10.1016/j.stem.2022.01.007.
[PubMed]
Cortical neural dynamics unveil the rhythm of natural visual behavior in marmosets.
Kaneko T, Komatsu M, Yamamori T, Ichinohe N, Okano H.
Commun Biol. 2022 Feb 3;5(1):108. doi: 10.1038/s42003-022-03052-1.
[PubMed]

Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice.
Imai C, Sano H, Quispe-Salcedo A, Saito K, Nakatomi M, Ida-Yonemochi H, Okano H, Ohshima H.
J Oral Biosci. 2022 Jan 11:S1349-0079(22)00001-9. doi: 10.1016/j.job.2022.01.001. [PubMed]

Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury.
Kitagawa T, Nagoshi N, Kamata Y, Kawai M, Ago K, Kajikawa K, Shibata R, Sato Y, Imaizumi K, Shindo T, Shinozaki M, Kohyama J, Shibata S, Matsumoto M, Nakamura M, Okano H.
Stem Cell Reports. 2022 doi: 10.1016/j.stemcr.2021.12.005.
[PubMed]