2022年

A set-theoretic definition of cell types with an algebraic structure on gene regulatory networks and application in annotation of RNA-seq data.

Yuji Okano, Yoshitaka Kase, Hideyuki Okano Stem Cell Rep. 2022
プレスリリース
Development of the stria vascularis in the common marmoset, a primate model.
Hosoya M, Kitama T, Iwabu K, Nishiyama T, Oishi N, Okano H, Ozawa H.
Sci Rep. 2022 Nov 17;12(1):19811. doi: 10.1038/s41598-022-24380-6.
PMID: 36396805

Chitinase-like protein 3: A novel niche factor for mouse neural stem cells.
Namiki J, Suzuki S, Shibata S, Kubota Y, Kaneko N, Yoshida K, Yamaguchi R, Matsuzaki Y, Masuda T, Ishihama Y, Sawamoto K, Okano H.
Stem Cell Reports. 2022 Nov 1:S2213-6711(22)00508-2. doi: 10.1016/j.stemcr.2022.10.012. Online ahead of print.
PMID: 36368330

The SYNGAP1 3’UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK.
Yokoi S, Ito T, Sahashi K, Nakatochi M, Nakamura R, Tohnai G, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y, Sobue G.
J Neurosci. 2022 Oct 13:JN-RM-0455-22. doi: 10.1523/JNEUROSCI.0455-22.2022. Online ahead of print.
PMID: 36261283

Effect of sedatives or anesthetics on the measurement of resting brain function in common marmosets.
Muta K, Hata J, Kawaguchi N, Haga Y, Yoshimaru D, Hagiya K, Kaneko T, Miyabe-Nishiwaki T, Komaki Y, Seki F, Okano HJ, Okano H.
Cereb Cortex. 2022 Oct 12:bhac406. doi: 10.1093/cercor/bhac406. Online ahead of print.
PMID: 36222604

Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms.
Ideno H, Imaizumi K, Shimada H, Sanosaka T, Nemoto A, Kohyama J, Okano H.
iScience. 2022 Sep 16;25(10):105140. doi: 10.1016/j.isci.2022.105140. eCollection 2022 Oct 21.
PMID: 36185382

Transplantation of neural progenitor cells into the human CNS.
Okano H.
Trends Mol Med. 2022 Nov;28(11):897-899. doi: 10.1016/j.molmed.2022.09.009. Epub 2022 Sep 29.
PMID: 36182630

A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer.
Shimada H, Sato Y, Sasaki T, Shimozawa A, Imaizumi K, Shindo T, Miyao S, Kiyama K, Kondo T, Shibata S, Ishii S, Kuromitsu J, Aoyagi H, Ito D, Okano H.
Cell Rep Methods. 2022 Sep 8;2(9):100289. doi: 10.1016/j.crmeth.2022.100289. eCollection 2022 Sep 19.
PMID: 36160042 プレスリリース

APOE Alleles With Tau and Aβ Pathology In Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula.
Sasaki R, Morimoto S, Ozawa F, Okano H, Yoshida M, Ishiura H, Tsuji S, Kuzuhara S, Kokubo Y.
Neurology. 2022 Sep 21:10.1212/WNL.0000000000201156. doi: 10.1212/WNL.0000000000201156. Online ahead of print.
PMID: 36130843

A combined stem-cell-gene therapy strategy for ALS. Okano H.
Nat Med. 2022 Sep 12. doi: 10.1038/s41591-022-01983-0. Online ahead of print.
PMID: 36097225

Long Preservation of AAV-Transduced Fluorescence by a Modified Organic Solvent-Based Clearing Method.
Lu T, Shinozaki M, Nagoshi N, Nakamura M, Okano H.
Int J Mol Sci. 2022 Aug 25;23(17):9637. doi: 10.3390/ijms23179637.
PMID: 36077034

Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter.
Yoshimatsu S, Seki F, Okahara J, Watanabe H, Sasaguri H, Haga Y, Hata JI, Sanosaka T, Inoue T, Mineshige T, Lee CY, Shinohara H, Kurotaki Y, Komaki Y, Kishi N, Murayama AY, Nagai Y, Minamimoto T, Yamamoto M, Nakajima M, Zhou Z, Nemoto A, Sato T, Ikeuchi T, Sahara N, Morimoto S, Shiozawa S, Saido TC, Sasaki E, Okano H.
Neurosci Res. 2022 Sep 6:S0168-0102(22)00232-2. doi: 10.1016/j.neures.2022.08.008. Online ahead of print.
PMID: 36075457

Accelerated neuronal aging in vitro ∼melting watch ∼.
Inagaki E, Yoshimatsu S, Okano H.
Front Aging Neurosci. 2022 Aug 9;14:868770. doi: 10.3389/fnagi.2022.868770. eCollection 2022.
PMID: 36016855

Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis.
Ito D, Morimoto S, Takahashi S, Okada K, Nakahara J, Okano H.
Brain. 2022 Aug 25:awac306. doi: 10.1093/brain/awac306. Online ahead of print.
PMID: 36004509

Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies.
Tsumagari K, Sato Y, Shimozawa A, Aoyagi H, Okano H, Kuromitsu J.
iScience. 2022 Aug 5;25(8):104832. doi: 10.1016/j.isci.2022.104832. eCollection 2022 Aug 19.
PMID: 35992067

A non-invasive system to monitor in vivo neural graft activity after spinal cord injury.
Ago K, Nagoshi N, Imaizumi K, Kitagawa T, Kawai M, Kajikawa K, Shibata R, Kamata Y, Kojima K, Shinozaki M, Kondo T, Iwano S, Miyawaki A, Ohtsuka M, Bito H, Kobayashi K, Shibata S, Shindo T, Kohyama J, Matsumoto M, Nakamura M, Okano H.
Commun Biol. 2022 Aug 10;5(1):803. doi: 10.1038/s42003-022-03736-8.
PMID: 35948599

biPACT: A method for three-dimensional visualization of mouse spinal cord circuits of long segments with high resolution.
Nakanishi K, Shinozaki M, Nagoshi N, Nakamura M, Okano H.
J Neurosci Methods. 2022 Sep 1;379:109672. doi: 10.1016/j.jneumeth.2022.109672. Epub 2022 Jul 16.
PMID: 35843371

Step-by-step protocols for non-viral derivation of transgene-free induced pluripotent stem cells from somatic fibroblasts of multiple mammalian species.
Yoshimatsu S, Yamazaki A, Edamura K, Koushige Y, Shibuya H, Qian E, Sato T, Okahara J, Kishi N, Noce T, Yamaguchi Y, Okano H.
Dev Growth Differ. 2022 Aug;64(6):325-341. doi: 10.1111/dgd.12798. Epub 2022 Aug 10.
PMID: 35841539

In Vivo Imaging Analysis of an Inner Ear Drug Delivery in Mice: Comparison of Inner Ear Drug Concentrations Over Time.
Kanzaki S, Shibata S, Nakamura M, Ozaki M, Okano H.
Methods Mol Biol. 2022;2524:327-332. doi: 10.1007/978-1-0716-2453-1_26.
PMID: 35821484

Generation of Stable Drosophila Ovarian Somatic Cell Lines Using the piggyBac System.
Takeuchi C, Murano K, Ishikawa M, Okano H, Iwasaki YW.
Methods Mol Biol. 2022;2509:143-153. doi: 10.1007/978-1-0716-2380-0_9.
PMID: 35796962

Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia.
Sonn I, Honda-Ozaki F, Yoshimatsu S, Morimoto S, Watanabe H, Okano H.
Inflamm Regen. 2022 Jul 1;42(1):20. doi: 10.1186/s41232-022-00201-1.
PMID: 35773727 プレスリリース

3D imaging of supraspinal inputs to the thoracic and lumbar spinal cord mapped by retrograde tracing and light-sheet microscopy.
Lu T, Shinozaki M, Nagoshi N, Nakamura M, Okano H.
J Neurochem. 2022 Jun 8. doi: 10.1111/jnc.15653. Online ahead of print.
PMID: 35674500

The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests.
Inagaki E, Arai E, Hatou S, Sayano T, Taniguchi H, Negishi K, Kanai Y, Sato Y, Okano H, Tsubota K, Shimmura S.
Stem Cells Transl Med. 2022 Jun 6:szac036. doi: 10.1093/stcltm/szac036. Online ahead of print.
PMID: 35666752

Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD.
Imaizumi K, Ideno H, Sato T, Morimoto S, Okano H.
eNeuro. 2022 Jun 8;9(3):ENEURO.0061-22.2022. doi: 10.1523/ENEURO.0061-22.2022. Print 2022 May-Jun.
PMID: 35641224

TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Morimoto Y, Tokumitsu A, Sone T, Hirota Y, Tamura R, Sakamoto A, Nakajima K, Toda M, Kawakami Y, Okano H, Ohta S.
Neurochem Res. 2022 May 27. doi: 10.1007/s11064-022-03629-6. Online ahead of print.
PMID: 35622214

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish.
Saeki T, Yoshimatsu S, Ishikawa M, Hon CC, Koya I, Shibata S, Hosoya M, Saegusa C, Ogawa K, Shin JW, Fujioka M, Okano H.
Regen Ther. 2022 May 16;20:165-186. doi: 10.1016/j.reth.2022.04.008. eCollection 2022 Jun.
PMID: 35620640

Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa.
Ozawa Y, Toda E, Homma K, Osada H, Nagai N, Tsubota K, Okano H.
Cells. 2022 Apr 29;11(9):1497. doi: 10.3390/cells11091497.
PMID: 35563803
Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer’s disease (AD) donor with multiple risk SNPs for sporadic Alzheimer’s disease (sAD).
Supakul S, Leventoux N, Tabuchi H, Mimura M, Ito D, Maeda S, Okano H.
Stem Cell Res. 2022 May 5;62:102802. doi: 10.1016/j.scr.2022.102802. Online ahead of print.
PMID: 35537244

Treadmill Training for Common Marmoset to Strengthen Corticospinal Connections After Thoracic Contusion Spinal Cord Injury.
Kondo T, Saito R, Sato Y, Sato K, Uchida A, Yoshino-Saito K, Shinozaki M, Tashiro S, Nagoshi N, Nakamura M, Ushiba J, Okano H.
Front Cell Neurosci. 2022 Apr 22;16:858562. doi: 10.3389/fncel.2022.858562. eCollection 2022.
PMID: 35530175

Early development of the cochlea of the common marmoset, a non-human primate model.
Hosoya M, Fujioka M, Okahara J, Yoshimatsu S, Okano H, Ozawa H.
Neural Dev. 2022 May 7;17(1):6. doi: 10.1186/s13064-022-00162-8.
PMID: 35524278

The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promot- ing microtubule polymerization.
Kase Y, Sato T, Okano Y, Okano H.
iScience 2022 April. link プレスリリース

Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy.
Kurihara S, Fujioka M, Hirabayashi M, Yoshida T, Hosoya M, Nagase M, Kato F, Ogawa K, Okano H, Kojima H, Okano HJ.
Stem Cells Transl Med. 2022 Mar 31;11(3):282-296. doi: 10.1093/stcltm/szab023.
[PubMed]

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice.
Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, Kubota Y.
J Exp Med. 2022 Apr 4;219(4):e20211789. doi: 10.1084/jem.20211789. Epub 2022 Mar 23.
[PubMed]

Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction.
Yanagisawa T, Ouchi T, Shibata S, Negishi T, Okano H.
Biochem Biophys Res Commun. 2022 Mar 3;603:49-56. doi: 10.1016/j.bbrc.2022.03.002. Online ahead of print.
[PubMed]

Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets.
Sato Y, Kondo T, Uchida A, Sato K, Yoshino-Saito K, Nakamura M, Okano H, Ushiba J.
Behav Brain Res. 2022 May 3;425:113816. doi: 10.1016/j.bbr.2022.113816. Epub 2022 Feb 26.
[PubMed]

Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies.
Tashiro S, Nakamura M, Okano H.
Cells. 2022 Feb 16;11(4):685. doi: 10.3390/cells11040685.
[PubMed]

Administration of C5a receptor antagonist improves the efficacy of human iPSCs-derived NS/PC transplantation in the acute phase of spinal cord injury.
Shibata R, Nagoshi N, Kajikawa K, Ito S, Shibata S, Shindo T, Khazaei M, Nori S, Kohyama J, Fehlings MG, Matsumoto M, Nakamura M, Okano H.
J Neurotrauma. 2022 Feb 24. doi: 10.1089/neu.2021.0225. Online ahead of print.
[PubMed]

Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset.
Yoshimatsu S, Nakajima M, Qian E, Sanosaka T, Sato T, Okano H.
Cells. 2022 Jan 21;11(3):360. doi: 10.3390/cells11030360.
[PubMed]

iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders.
Okano H, Morimoto S.
Cell Stem Cell. 2022 Feb 3;29(2):189-208. doi: 10.1016/j.stem.2022.01.007.
[PubMed]
Cortical neural dynamics unveil the rhythm of natural visual behavior in marmosets.
Kaneko T, Komatsu M, Yamamori T, Ichinohe N, Okano H.
Commun Biol. 2022 Feb 3;5(1):108. doi: 10.1038/s42003-022-03052-1.
[PubMed]

Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice.
Imai C, Sano H, Quispe-Salcedo A, Saito K, Nakatomi M, Ida-Yonemochi H, Okano H, Ohshima H.
J Oral Biosci. 2022 Jan 11:S1349-0079(22)00001-9. doi: 10.1016/j.job.2022.01.001. [PubMed]

Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury.
Kitagawa T, Nagoshi N, Kamata Y, Kawai M, Ago K, Kajikawa K, Shibata R, Sato Y, Imaizumi K, Shindo T, Shinozaki M, Kohyama J, Shibata S, Matsumoto M, Nakamura M, Okano H.
Stem Cell Reports. 2022 doi: 10.1016/j.stemcr.2021.12.005.
[PubMed]