2014年

Fujioka M, Okano H, Ogawa K. Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss. Front Pharmacol. 2014 Dec 23;5:287. doi: 10.3389 [PubMed]

Shibata S, Komaki Y, Seki F, Inouye MO, Nagai T, Okano H. Connectomics: comprehensive approaches for whole-brain mapping. Microscopy (Oxf). 2014 Dec 18. pii: dfu103. [Epub ahead of print] [PubMed]

Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, Nakamura M, Okano H. BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2. Neurorehabil Neural Repair. 2014 Dec 19. pii: 1545968314562110. [Epub ahead of print] [PubMed]

Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T. Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses. Biol Psychiatry. 2014 Sep 11. pii: S0006-3223(14)00570-8. doi: 10.1016 [PubMed]

Zhang H, Tan E, Suzuki Y, Hirose Y, Kinoshita S, Okano H, Kudoh J, Shimizu A, Saito K, Watabe S, Asakawa S. Dramatic improvement in genome assembly achieved using doubled-haploid genomes. Sci Rep. 2014 Oct 27;4:6780. doi: 10.1038 [PubMed]

Hayashi S, Yano M, Igarashi M, Okano HJ, Okano H. Alternative Role of HuD Splicing Variants in Neuronal Differentiation. J Neurosci Res. 2015 Mar; 93(3):399-409. [PubMed]

Kuwako K, Nishimoto Y, Kawase S, Okano HJ, Okano H. Cadherin-7 Regulates Mossy Fiber Connectivity in the Cerebellum.  Cell Rep. 2014 Oct 9;9(1):311-23. [PubMed] 

Okano H, Mitra P. Brain-mapping projects using the common marmoset. Neurosci Res. 2014 Sep 27. pii: S0168-0102(14)00190-4. doi: 10.1016/j.neures.2014.08.014. [Epub ahead of print] [PubMed]

Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H. Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice. Stem Cell Reports. 2014 Aug 12;3(2):242-9. doi: 10.1016 [PubMed]

Takemi M, Kondo T, Yoshino-Saito K, Sekiguchi T, Kosugi A, Kasuga S, Okano HJ, Okano H, Ushiba J. Three-dimensional motion analysis of arm-reaching movements in healthy and hemispinalized common marmosets. Behav Brain Res. 2014 Dec 15;275:259-68. doi: 10.1016. [PubMed]

Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung’s disease. Cytotechnology. 2014 Sep 18. [Epub ahead of print][PubMed]

Okano H. Stem cell research and regenerative medicine in 2014: first year of regenerative medicine in Japan. Stem Cells Dev. 2014 Sep 15;23(18):2127-2128 [PubMed]

Matsuzaki Y, Mabuchi Y, Okano H. Leptin Receptor Makes Its Mark on MSCs. Cell Stem Cell. 2014 Aug 7;15(2):112-4. [PubMed]

Kawase S, Kuwako K, Imai T, Renault-Mihara F, Yaguchi K, Itohara S, Okano H. Rfx Transcription Factors Control Musashi1 Transcription in Mouse Neural Stem/Progenitor Cells. Stem Cells Dev.  2014 Sep 15;23(18):2250-61. [PubMed]

Yano M, Ohtsuka T, Okano H. RNA-binding protein research with transcriptome-wide technologies in neural development. Cell Tissue Res. 2015 Jan;359(1):135-44. [PubMed]

Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC. Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly. Cell Rep. 2014 Jul 10;8(1):103-13. [PubMed]

Yamada I, Hikishima K, Miyasaka N, Tokairin Y, Ito E, Kawano T, Kobayashi D, Eishi Y, Okano H. Esophageal carcinoma: Evaluation with q-space diffusion-weighted MR imaging ex vivo. Magn Reson Med. 2014 Jun 19. doi: 10.1002 [Epub ahead of print] [PubMed]

Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H. Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes. Stem Cell Reports. 2014 Apr 24;2(5):648-61. doi: 10.1016 [PubMed]

Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Mol Brain. 2014 Jun 16;7(1):45. doi: 10.1186 [PubMed]

Yamada I, Hikishima K, Miyasaka N, Tokairin Y, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H, Shibuya H. Diffusion-tensor MRI and tractography of the esophageal wall ex vivo. J Magn Reson Imaging.2014 Sep;40(3):567-76. doi: 10.1002 [PubMed]

Hirano T, Iwasaki YW, Lin ZY, Imamura M, Seki NM, Sasaki E, Saito K, Okano H, Siomi MC, Siomi H. Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. RNA. 2014 Aug;20(8):1223-37. doi: 10.1261 [PubMed]

Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Iakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson AJ, Okano H, Nakamura M. Global gene expression analysis following spinal cord injury in non-human primates. Exp Neurol.  2014 Nov;261:171-9.doi: 10.1016 [PubMed]

Sakuraba M, Murata J, Teruyama R, Kamiya K, Yamaguchi J, Okano H, Uchiyama Y, Ikeda K. Spatiotemporal expression of TRPM4 in the mouse cochlea. J Neurosci Res. 2014 Oct;92(10):1409-18. doi: 10.1002/jnr.23410. Epub 2014 May 20. [PubMed]

Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Control of the survival and growth of human glioblastoma grafted into the spinal cord of mice by taking advantage of immunorejection. Cell Transplant. 2014 May 9. [Epub ahead of print] [PubMed]

Kato M, Okanoya K, Koike T, Sasaki E, Okano H, Watanabe S, Iriki A. Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain. Brain Lang. 2014 Jun;133:26-38. doi: 10.1016[PubMed]

Bamba Y, Shofuda T, Kanematsu D, Nonaka M, Yamasaki M, Okano H, Kanemura Y. Differentiation, polarization, and migration of human induced pluripotent stem cell-derived neural progenitor cells co-cultured with a human glial cell line with radial glial-like characteristics. Biochem Biophys Res Commun. 014 May 16;447(4):683-8. doi: 10.1016 [PubMed]

Takahashi T, Hanazawa K, Inoue T, Sato K, Sedohara A, Okahara J, Suemizu H, Yagihashi C, Yamamoto M, Eto T, Konno Y, Okano H, Suematsu M, Sasaki E. Birth of Healthy Offspring following ICSI in In Vitro-Matured Common Marmoset (Callithrix jacchus) Oocytes.  PLoS One. 2014 Apr 21;9(4):e95560. doi: 10.1371  [PubMed]

Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H. Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients. Leukemia. 2014 Apr 15. doi: 10.1038 [Epub ahead of print] [PubMed]

Zhou Z, Kohda K, Ibata K, Kohyama J, Akamatsu W, Yuzaki M, Okano HJ, Sasaki E, Okano H. Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors. Mol Brain. 2014 Apr 3;7(1):24. doi: 10.1186[PubMed]

Okano H, Yamanaka S. iPS cell technologies: significance and applications to CNS regeneration and disease. Mol Brain. 2014 Mar 31;7(1):22. doi: 10.1186[PubMed]

Yamada I, Hikishima K, Miyasaka N, Kawano T, Tokairin Y, Ito E, Kobayashi D, Eishi Y, Okano H. Esophageal Carcinoma: Ex Vivo Evaluation with Diffusion-Tensor MR Imaging and Tractography at 7 T. Radiology. 2014 Jul;272(1):164-73. doi: 10.1148[PubMed]

Itaba N, Wairagu PM, Aramaki N, Yasui T, Matsumi Y, Kono Y, Phan AN, Otsu M, Kunisada T, Nakamura Y, Okano H, Jeong Y, Shiota G. Nuclear receptor gene alteration in human induced pluripotent stem cells with hepatic differentiation propensity. Hepatol Res. 2014 Mar 18. doi: 10.1111 [Epub ahead of print] [PubMed]

Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H1, Nakamura M. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain. 2014 Mar 10;7(1):14. doi: 10.1186 [PubMed]

Fujioka M, Okamoto Y, Shinden S, Okano HJ, Okano H, Ogawa K, Matsunaga T. Pharmacological inhibition of cochlear mitochondrial respiratory chain induces secondary inflammation in the lateral wall: a potential therapeutic target for sensorineural hearing loss. PLoS One. 2014 Mar 10;9(3):e90089 doi: 10.1371 [PubMed]

Deboer EM, Azevedo R, Vega TA, Brodkin J, Akamatsu W, Okano H, Wagner GC, Rasin MR. Prenatal Deletion of the RNA-Binding Protein HuD Disrupts Postnatal Cortical Circuit Maturation and Behavior. J Neurosci.  2014 Mar 5;34(10):3674-86. doi: 10.1523 [PubMed]

Nakamura S, Igarashi M, Kinoshita M, Okano HJ, Okano H. Proposing a new RNA quadruplex structure: j-motif, with possible links to neural development. J Biochem. 2014 Jun;155(6):385-92. doi: 10.1093 [PubMed]

Takano M, Kawabata S, Komaki Y, Shibata S, Hikishima K, Toyama Y, Okano H, Nakamura M. Inflammatory cascades mediate synapse elimination in spinal cord compression. J Neuroinflammation. 2014 Mar 4;11:40. doi: 10.1186 [PubMed]

Bae B-I, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Murayama A, Im K, Crosier M, Lisgo SN, Lindsay S, Šestan N, Bernard S. Chang BS, Barkovich J, Grant E,Topçu M, Politsky J, Okano H, Piao X, and Walsh CA: Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning. Science 343 (6172): 764-768, 2014. [PubMed]

Yamashita A, Hamada A, Suhara Y, Kawabe R, Yanase M, Kuzumaki N, Narita M, Matsui R, Okano H, Narita M. Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain. Synapse. 2014 Jun;68(6):235-47. doi: 10.1002 [PubMed]

Yamaguchi S, Marumoto T, Nii T, Kawano H, Liao J, Nagai Y, Okada M, Takahashi A, Inoue H, Sasaki E, Fujii H, Okano S, Ebise H, Sato T, Suyama M, Okano H, Miura Y, Tani K. Characterization of common marmoset dysgerminoma like tumor induced by the lentiviral expression of reprogramming factors.Cancer Sci. 2014 Apr;105(4):402-8. doi: 10.1111[PubMed]

Naka-Kaneda H, Nakamura S, Igarashi M, Aoi H, Kanki H, TsutsumiS, Aburatani H, Shimazaki T and Okano H: The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic competence transition in developing neural stem/progenitor cells. Proc.Natl.Acad.Sci.USA 111(4):1604-1609, 2014.[PubMed]

Tomioka T, Shimazaki T, Yamauchi T, Oki T, Ohgoh M, Okano H. LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop. J Biol Chem.
289(2):1000-1010, 2014. [PubMed]

Kim C, Kim W, Lee H, Ji E, Choe YJ, Martindale JL, Akamatsu W, Okano H, Kim HS, Nam SW, Gorospe M, Lee EK.: The RNA binding protein, HuD regulates autophagosome formation in pancreatic b cells by promoting autophagy-related
gene 5 expression. J Biol Chem. 289(1):112-121, 2014. [PubMed]

Sawada K, Hikishima K, Murayama AY, Okano HJ, Sasaki E, Okano H.: Fetal sulcation and gyrification in common marmosets (Callithrix Jacchus) obtained by ex
vivo magnetic resonance imaging. Neuroscience. 230: 102-113, 2014. [PubMed]

Bundo M,Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi
T, Sunaga F, Toritsuka M, Ikawa D,  Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H,Yoshikawa T,Kato T, and  Iwamoto K: Increased L1 Retrotransposition in the neuronal genome in Schizophrenia. Neuron 81(2):306-313, 2014. [PubMed]

Shinozaki M, Nakamura M, Konomi T, Kobayashi Y, Takano M, Saito N, Toyama Y, Okano H. Distinct roles of endogenous vascular endothelial factor receptor 1 and 2 in neural protection after spinal cord injury. Neurosci Res. 78:55-64, 2014. [PubMed]

Ohyama M, Okano H.: Promise of human induced pluripotent stem cells in
skin regeneration and investigation. J Invest Dermatol.  134(3):605-609., 2014. [PubMed]

Imamura M, Hikabe O, Lin ZY, Okano H. Generation of germ cells in vitro in the era of induced pluripotent stem cells. Mol Reprod Dev. 81(1):2-19, 2014. [PubMed]

Kishi N, Sato K, Sasaki E, Okano H. Common marmoset as a new model animal for neuroscience research and genome editing technology. Dev Growth Differ. 2014 Jan;56(1):53-62. [PubMed]