2021年

Influence of a clinical trial in the decision-making processes of patients with amyotrophic lateral sclerosis.Kato C, Morimoto S, Takahashi S, Daté Y, Okada K, Okano H, Nakahara J, Ito D.
J Neurol. 2021 Oct 25. doi: 10.1007/s00415-021-10862-6. Online ahead of print.PMID: 34694425 [PubMed]

Mechanisms of Stem Cell Therapy in Spinal Cord Injuries.
Shinozaki M, Nagoshi N, Nakamura M, Okano H.
Cells. 2021 Oct 6;10(10):2676. doi: 10.3390/cells10102676.
PMID: 34685655[PubMed]

LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury.
Ito S, Nagoshi N, Kamata Y, Kojima K, Nori S, Matsumoto M, Takei K, Nakamura M, Okano H. Stem Cell Reports. 2021 Sep 27:S2213-6711(21)00482-3. doi: 10.1016/j.stemcr.2021.09.006. Online ahead of print.
PMID: 34653401 [PubMed][プレスリリース]

 

Generation of a control human induced pluripotent stem cell line using the defective and persistent Sendai virus vector system.
Zhou Z, Yoshimatsu S, Qian E, Ishikawa M, Sato T, Ohtaka M, Nakanishi M, Okano H.
Stem Cell Res. 2021 Sep 23;56:102549. doi: 10.1016/j.scr.2021.102549. Online ahead of print.
PMID: 34598113 [PubMed]

Neuronal development in the cochlea of a nonhuman primate model, the common marmoset.
Hosoya M, Fujioka M, Murayama AY, Ozawa H, Okano H, Ogawa K.
Dev Neurobiol. 2021 Sep 21. doi: 10.1002/dneu.22850. Online ahead of print.
PMID: 34545999 [PubMed]

First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol.
Sugai K, Sumida M, Shofuda T, Yamaguchi R, Tamura T, Kohzuki T, Abe T, Shibata R, Kamata Y, Ito S, Okubo T, Tsuji O, Nori S, Nagoshi N, Yamanaka S, Kawamata S, Kanemura Y, Nakamura M, Okano H.
Regen Ther. 2021 Sep 7;18:321-333. doi: 10.1016/j.reth.2021.08.005. eCollection 2021 Dec. PMID: 34522725 [PubMed]

Markerless analysis of hindlimb kinematics in spinal cord-injured mice through deep learning.
Sato Y, Kondo T, Shinozaki M, Shibata R, Nagoshi N, Ushiba J, Nakamura M, Okano H.
Neurosci Res. 2021 Sep 8:S0168-0102(21)00203-0. doi: 10.1016/j.neures.2021.09.001.  PMID: 34508755 [PubMed]

Modeling human congenital disorders with neural crest developmental defects using patient-derived induced pluripotent stem cells.
Okuno H, Okano H.
Regen Ther. 2021 Aug 24;18:275-280. doi: 10.1016/j.reth.2021.08.001. eCollection 2021 Dec. PMID: 34504908 [PubMed]

Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons.
Toritsuka M, Yoshino H, Makinodan M, Ikawa D, Kimoto S, Yamamuro K, Okamura K, Akamatsu W, Okada Y, Matsumoto T, Hashimoto K, Ogawa Y, Saito Y, Watanabe K, Aoki C, Takada R, Fukami SI, Hamano-Iwasa K, Okano H, Kishimoto T.
Neurochem Int. 2021 Sep 6;150:105179. doi: 10.1016/j.neuint.2021.105179. Online ahead of print. PMID: 34500023 [PubMed]

Comparison of Drug Availability in the Inner Ear After Oral, Transtympanic, and Combined Administration.
Li Y, Kanzaki S, Shibata S, Nakamura M, Ozaki M, Okano H, Ogawa K.
Front Neurol. 2021 Aug 19;12:641593. doi: 10.3389/fneur.2021.641593. eCollection 2021. PMID: 34497573 [PubMed]

NEAT1 lncRNA and amyotrophic lateral sclerosis.
Nishimoto Y, Nakagawa S, Okano H.
Neurochem Int. 2021 Sep 2;150:105175. doi: 10.1016/j.neuint.2021.105175. Online ahead of print. PMID: 34481908 [PubMed]

Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model.
Hatou S, Sayano T, Higa K, Inagaki E, Okano Y, Sato Y, Okano H, Tsubota K, Shimmura S.
Stem Cell Res. 2021 Aug 9;55:102497. doi: 10.1016/j.scr.2021.102497. Online ahead of print. PMID: 34411973 [PubMed]

Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures.
Fukuyama M, Tsukashima A, Kimishima M, Yamazaki Y, Okano H, Ohyama M.
Front Cell Dev Biol. 2021 Aug 2;9:590333. doi: 10.3389/fcell.2021.590333. eCollection 2021. PMID: 34409023 [PubMed]

Treadmill training based on the overload principle promotes locomotor recovery in a mouse model of chronic spinal cord injury.
Shibata T, Tashiro S, Shinozaki M, Hashimoto S, Matsumoto M, Nakamura M, Okano H, Nagoshi N.
Exp Neurol. 2021 Aug 8;345:113834. doi: 10.1016/j.expneurol.2021.113834. Online ahead of print. PMID: 34370998[PubMed]

Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate’s Cochlea.
Hosoya M, Fujioka M, Murayama AY, Ogawa K, Okano H, Ozawa H.
Genes (Basel). 2021 Jul 16;12(7):1082. doi: 10.3390/genes12071082. PMID: 34356098 [PubMed]

Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice.
Abe Y, Kwon S, Oishi M, Unekawa M, Takata N, Seki F, Koyama R, Abe M, Sakimura K, Masamoto K, Tomita Y, Okano H, Mushiake H, Tanaka KF.
Cell Rep. 2021 Jul 27;36(4):109427. doi: 10.1016/j.celrep.2021.109427. PMID: 34320360 [PubMed]

Current Status of and Perspectives on the Application of Marmosets in Neurobiology.
Okano H. Annu Rev Neurosci. 2021 Jul 8;44:27-48. doi: 10.1146/annurev-neuro-030520-101844. Epub 2020 Dec 2. PMID: 34236888 [PubMed]

Involvement of ferroptosis in human motor neuron cell death.
Matsuo T, Adachi-Tominari K, Sano O, Kamei T, Nogami M, Ogi K, Okano H, Yano M.
Biochem Biophys Res Commun. 2021 Aug 20;566:24-29. doi: 10.1016/j.bbrc.2021.05.095. Epub 2021 Jun 7. PMID: 34111668 [PubMed]

Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability.
Yoshimatsu S, Murakami R, Nakajima M, Sato T, Kawasaki H, Okano H.
Stem Cell Res. 2021 May;53:102385. doi: 10.1016/j.scr.2021.102385. Epub 2021 May 11.
PMID: 34088013 [PubMed]
Establishing an induced pluripotent stem cell line from neonatal common marmoset fibroblasts by an all-in-one episomal vector approach.
Yoshimatsu S, Qian E, Sato T, Yamamoto M, Ishikawa M, Okano H.
Stem Cell Res. 2021 May;53:102380. doi: 10.1016/j.scr.2021.102380. Epub 2021 Apr 30.
PMID: 34088009 [PubMed]

Non-viral derivation of a transgene-free induced pluripotent stem cell line from a male beagle dog.
Yoshimatsu S, Edamura K, Yoshii Y, Iguchi A, Kondo H, Shibuya H, Sato T, Shiozawa S, Okano H.
Stem Cell Res. 2021 May;53:102375. doi: 10.1016/j.scr.2021.102375. Epub 2021 Apr 29.
PMID: 34088004 [PubMed]

Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations.
Mitsuzawa S, Suzuki N, Akiyama T, Ishikawa M, Sone T, Kawada J, Funayama R, Shirota M, Mitsuhashi H, Morimoto S, Ikeda K, Shijo T, Ohno A, Nakamura N, Ono H, Ono R, Osana S, Nakagawa T, Nishiyama A, Izumi R, Kaneda S, Ikeuchi Y, Nakayama K, Fujii T, Warita H, Okano H, Aoki M.
Stem Cell Reports. 2021 Jun 8;16(6):1527-1541. doi: 10.1016/j.stemcr.2021.04.021. Epub 2021 May 27.
PMID: 34048688 [PubMed] [プレスリリース]

MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Nakashima H, Tsujimura K, Irie K, Imamura T, Trujillo CA, Ishizu M, Uesaka M, Pan M, Noguchi H, Okada K, Aoyagi K, Andoh-Noda T, Okano H, Muotri AR, Nakashima K.
Cell Rep. 2021 May 18;35(7):109124. doi: 10.1016/j.celrep.2021.109124.
PMID: 34010654 [PubMed] [プレスリリース]

Neurological pathogenesis of SARS-CoV-2 (COVID-19): from virological features to clinical symptoms.
Kase Y, Okano H.
Inflamm Regen. 2021 May 7;41(1):15. doi: 10.1186/s41232-021-00165-8.
PMID: 33962695 [PubMed]

Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons.
Ichise E, Chiyonobu T, Ishikawa M, Tanaka Y, Shibata M, Tozawa T, Taura Y, Yamashita S, Yoshida M, Morimoto M, Higurashi N, Yamamoto T, Okano H, Hirose S.
Hum Mol Genet. 2021 May 7:ddab113. doi: 10.1093/hmg/ddab113. Online ahead of print.
PMID: 33961044 [PubMed]

Amyloid β (Aβ) ELISA of Human iPSC-Derived Neuronal Cultures.
Watanabe H, Murakami R, Okano H.
Methods Mol Biol. 2021 May 7. doi: 10.1007/7651_2021_407. Online ahead of print.
PMID: 33959916 [PubMed]

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.
Deshimaru M, Kinoshita-Kawada M, Kubota K, Watanabe T, Tanaka Y, Hirano S, Ishidate F, Hiramoto M, Ishikawa M, Uehara Y, Okano H, Hirose S, Fujioka S, Iwasaki K, Yuasa-Kawada J, Mishima T, Tsuboi Y.
Int J Mol Sci. 2021 Apr 13;22(8):3985. doi: 10.3390/ijms22083985.
PMID: 33924373 [PubMed]

A new approach to analysis of intracellular proteins and subcellular localization using cellprofiler and imageJ in combination.
Hattori A, Ohta E, Nagai M, Iwabuchi K, Okano H.
Methods. 2021 Apr 26:S1046-2023(21)00111-0. doi: 10.1016/j.ymeth.2021.04.019. Online ahead of print.
PMID: 33915291 [PubMed]

Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians.
Sasaki T, Abe Y, Takayama M, Adachi T, Okano H, Hirose N, Arai Y.
Sci Rep. 2021 Apr 20;11(1):8539. doi: 10.1038/s41598-021-87982-6.
PMID: 33879836 [PubMed]

Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN.
Nogami M, Ishikawa M, Doi A, Sano O, Sone T, Akiyama T, Aoki M, Nakanishi A, Ogi K, Yano M, Okano H.
Neurobiol Dis. 2021 Apr 12:105364. doi: 10.1016/j.nbd.2021.105364. Online ahead of print. PMID: 33857636[PubMed] [プレスリリース]

Generation of a common marmoset embryonic stem cell line CMES40-OC harboring a POU5F1 (OCT4)-2A-mCerulean3 knock-in reporter allele.
Yoshimatsu S, Murakami R, Sato T, Saeki T, Yamamoto M, Sasaki E, Noce T, Okano H.
Stem Cell Res. 2021 Mar 24;53:102308. doi: 10.1016/j.scr.2021.102308. Online ahead of print. PMID: 33799281 [PubMed]

Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species.
Yoshimatsu S, Nakajima M, Iguchi A, Sanosaka T, Sato T, Nakamura M, Nakajima R, Arai E, Ishikawa M, Imaizumi K, Watanabe H, Okahara J, Noce T, Takeda Y, Sasaki E, Behr R, Edamura K, Shiozawa S, Okano H.
Stem Cell Reports. 2021 Apr 13;16(4):754-770. doi: 10.1016/j.stemcr.2021.03.002. Epub 2021 Apr 1. PMID: 33798453 [PubMed] [プレスリリース]

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons.
Yokota M, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M.
Mol Brain. 2021 Mar 23;14(1):58. doi: 10.1186/s13041-021-00771-0.
PMID: 33757554 [PubMed]

β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells.
Chee WY, Kurahashi Y, Kim J, Miura K, Okuzaki D, Ishitani T, Kajiwara K, Nada S, Okano H, Okada M.
Commun Biol. 2021 Mar 19;4(1):357. doi: 10.1038/s42003-021-01879-8.
PMID: 33742113 [PubMed]

Integrated Collection of Stem Cell Bank Data, a Data Portal for Standardized Stem Cell Information.
Chen Y, Sakurai K, Maeda S, Masui T, Okano H, Dewender J, Seltmann S, Kurtz A, Masuya H, Nakamura Y, Sheldon M, Schneider J, Stacey GN, Panina Y, Fujibuchi W.
Stem Cell Reports. 2021 Mar 10:S2213-6711(21)00094-1. doi: 10.1016/j.stemcr.2021.02.014. Online ahead of print.
PMID: 33740463 [PubMed]

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M.
Mol Ther Nucleic Acids. 2021 Feb 15;24:1-10. doi: 10.1016/j.omtn.2021.02.007. eCollection 2021 Jun 4.
PMID: 33738134 [PubMed]

Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy.
Takata N, Sato N, Komaki Y, Okano H, Tanaka KF.
Sci Rep. 2021 Mar 18;11(1):6234. doi: 10.1038/s41598-021-85807-0.
PMID: 33737651 [PubMed]

Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium.
Homma K, Toda E, Osada H, Nagai N, Era T, Tsubota K, Okano H, Ozawa Y.
Redox Biol. 2021 Feb 28;41:101921. doi: 10.1016/j.redox.2021.101921. Online ahead of print.
PMID: 33706170 [PubMed]

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
Watanabe H, Imaizumi K, Cai T, Zhou Z, Tomita T, Okano H.
eNeuro. 2021 Mar 3;8(2):ENEURO.0500-20.2021. doi: 10.1523/ENEURO.0500-20.2021. Print 2021 Mar-Apr.
PMID: 33608391 [PubMed][プレスリリース]

DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2.
Nogami M, Miyamoto K, Hayakawa-Yano Y, Nakanishi A, Yano M, Okano H.
J Biol Chem. 2021 Feb 10:100409. doi: 10.1016/j.jbc.2021.100409. Online ahead of print.
PMID: 33581109 [PubMed]

Generation of region-specific and high-purity neurons from human feeder-free iPSCs.
Sato T, Imaizumi K, Watanabe H, Ishikawa M, Okano H.
Neurosci Lett. 2021 Feb 16;746:135676. doi: 10.1016/j.neulet.2021.135676. Epub 2021 Jan 28.
PMID: 33516803 [PubMed]
Generation and validation of a common marmoset embryonic stem cell line ActiCre-B1 that ubiquitously expresses a tamoxifen-inducible Cre-driver.
Yoshimatsu S, Ohtsu K, Sato T, Yamamoto M, Sasaki E, Shiozawa S, Okano H.
Stem Cell Res. 2021 Mar;51:102164. doi: 10.1016/j.scr.2021.102164. Epub 2021 Jan 8.
PMID: 33453576 [PubMed]

Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration.
Ishii S, Sasaki T, Mohammad S, Hwang H, Tomy E, Somaa F, Ishibashi N, Okano H, Rakic P, Hashimoto-Torii K, Torii M. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2012482118. doi: 10.1073/pnas.2012482118. Epub 2020 Dec 21.
PMID: 33443207 [PubMed]