2021年

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons.
Yokota M, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M.
Mol Brain. 2021 Mar 23;14(1):58. doi: 10.1186/s13041-021-00771-0.
PMID: 33757554 [PubMed]

β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells.
Chee WY, Kurahashi Y, Kim J, Miura K, Okuzaki D, Ishitani T, Kajiwara K, Nada S, Okano H, Okada M.
Commun Biol. 2021 Mar 19;4(1):357. doi: 10.1038/s42003-021-01879-8.
PMID: 33742113 [PubMed]

Integrated Collection of Stem Cell Bank Data, a Data Portal for Standardized Stem Cell Information.
Chen Y, Sakurai K, Maeda S, Masui T, Okano H, Dewender J, Seltmann S, Kurtz A, Masuya H, Nakamura Y, Sheldon M, Schneider J, Stacey GN, Panina Y, Fujibuchi W.
Stem Cell Reports. 2021 Mar 10:S2213-6711(21)00094-1. doi: 10.1016/j.stemcr.2021.02.014. Online ahead of print.
PMID: 33740463 [PubMed]

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M.
Mol Ther Nucleic Acids. 2021 Feb 15;24:1-10. doi: 10.1016/j.omtn.2021.02.007. eCollection 2021 Jun 4.
PMID: 33738134 [PubMed]

Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy.
Takata N, Sato N, Komaki Y, Okano H, Tanaka KF.
Sci Rep. 2021 Mar 18;11(1):6234. doi: 10.1038/s41598-021-85807-0.
PMID: 33737651 [PubMed]

Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium.
Homma K, Toda E, Osada H, Nagai N, Era T, Tsubota K, Okano H, Ozawa Y.
Redox Biol. 2021 Feb 28;41:101921. doi: 10.1016/j.redox.2021.101921. Online ahead of print.
PMID: 33706170 [PubMed]

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
Watanabe H, Imaizumi K, Cai T, Zhou Z, Tomita T, Okano H.
eNeuro. 2021 Mar 3;8(2):ENEURO.0500-20.2021. doi: 10.1523/ENEURO.0500-20.2021. Print 2021 Mar-Apr.
PMID: 33608391 [PubMed][プレスリリース]

DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2.
Nogami M, Miyamoto K, Hayakawa-Yano Y, Nakanishi A, Yano M, Okano H.
J Biol Chem. 2021 Feb 10:100409. doi: 10.1016/j.jbc.2021.100409. Online ahead of print.
PMID: 33581109 [PubMed]

Generation of region-specific and high-purity neurons from human feeder-free iPSCs.
Sato T, Imaizumi K, Watanabe H, Ishikawa M, Okano H.
Neurosci Lett. 2021 Feb 16;746:135676. doi: 10.1016/j.neulet.2021.135676. Epub 2021 Jan 28.
PMID: 33516803 [PubMed]
Generation and validation of a common marmoset embryonic stem cell line ActiCre-B1 that ubiquitously expresses a tamoxifen-inducible Cre-driver.
Yoshimatsu S, Ohtsu K, Sato T, Yamamoto M, Sasaki E, Shiozawa S, Okano H.
Stem Cell Res. 2021 Mar;51:102164. doi: 10.1016/j.scr.2021.102164. Epub 2021 Jan 8.
PMID: 33453576 [PubMed]

Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration.
Ishii S, Sasaki T, Mohammad S, Hwang H, Tomy E, Somaa F, Ishibashi N, Okano H, Rakic P, Hashimoto-Torii K, Torii M. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2012482118. doi: 10.1073/pnas.2012482118. Epub 2020 Dec 21.
PMID: 33443207 [PubMed]