2020年

“miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro” M Ishikawa, T Aoyama, S Shibata , T Sone, H Miyoshi, H Watanabe, M Nakamura, S Morota, H Uchino, A Yoo, H Okano. Cells PMID: 32106535 DOI: 10.3390/cells9030532 [PubMed]

“Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.” Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, Gotoda-Nishimura N, Igarashi H, Hayashida M, Baba M, Kondo M, Hasebe S, Ueshima K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Yamaguchi S, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T.
Nat Commun. 2020 Feb 26;11(1):859. doi: 10.1038/s41467-020-14697-z. [PubMed]

“Awake functional MRI detects neural circuit dysfunction in a mouse model of autism.” Tsurugizawa T, Tamada K, Ono N, Karakawa S, Kodama Y, Debacker C, Hata J, Okano H, Kitamura A, Zalesky A, Takumi T.
Sci Adv. 2020 Feb 5;6(6):eaav4520. doi: 10.1126/sciadv.aav4520. eCollection 2020 Feb. [PubMed]

“Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect.” Tamura R, Miyoshi H, Morimoto Y, Oishi Y, Sampetrean O, Iwasawa C, Mine Y, Saya H, Yoshida K, Okano H, Toda M.
Hum Gene Ther. 2020 Feb 19. doi: 10.1089/hum.2019.326. [PubMed]

“Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs.” Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, de Araújo Herculano B, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y.
Mol Brain. 2020 Feb 19;13(1):18. doi: 10.1186/s13041-020-0561-1. [PubMed] プレスリリース

“Reprogramming of chimpanzee fibroblasts into a multipotent cancerous but not fully pluripotent state by transducing iPSC factors in 2i/LIF culture.”
Lin ZY, Nakai R, Hirai H, Kozuka D, Katayama S, Nakamura SI, Okada S, Kitajima R, Imai H, Okano H, Imamura M
Differentiation 2020 Feb 4;112:67-76. doi: 10.1016/j.diff.2020.01.002. [PubMed]

“YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology.”
Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H.
Nat Commun. 2020 Jan 24;11(1):507. doi: 10.1038/s41467-020-14353-6. [PubMed]

“In vivo monitoring of remnant undifferentiated neural cells following human iPS cell-derived neural stem/progenitor cells transplantation.”
Tanimoto Y, Yamasaki T, Nagoshi N, Nishiyama Y, Nori S, Nishimura S, Iida T, Ozaki M, Tsuji O, Ji B, Aoki I, Jinzaki M, Matsumoto M, Fujibayashi Y, Zhang MR, Nakamura M, Okano H. Stem Cells Transl Med. 2020 Jan 6. doi: 10.1002/sctm.19-0150. [PubMed] プレスリリース 

“Ropinirole, a New ALS Drug Candidate Developed Using iPSCs.”
Okano H, Yasuda D, Fujimori K, Morimoto S, Takahashi S.
Trends Pharmacol Sci. 2020 Jan 8. pii: S0165-6147(19)30274-3. doi: 10.1016/j.tips.2019.12.002. [PubMed]