2019年

Kumita W, Sato K, Suzuki Y, Kurotaki Y, Harada T, Zhou Y, Kishi N, Sato K, Aiba A, Sakakibara Y, Feng G, Okano H, Sasaki E. Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing. Sci Rep. 2019 Sep 3;9(1):12719. doi: 10.1038/s41598-019-49110-3. [PubMed]

Yoshimatsu S, Sone T, Nakajima M, Sato T, Okochi R, Ishikawa M, Nakamura M, Sasaki E, Shiozawa S, Okano H. A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology. PLoS One. 2019 Aug 27;14(8):e0221164. doi: 10.1371/journal.pone.0221164. [PubMed]

Lohmeier J, Kaneko T, Hamm B, Makowski MR, Okano H. atlasBREX: Automated template-derived brain extraction in animal MRI. Sci Rep. 2019 Aug 21;9(1):12219. doi: 10.1038/s41598-019-48489-3. [PubMed]

Cheng YF, Chan YH, Hu CJ, Lu YC, Saeki T, Hosoya M, Saegusa C, Fujioka M, Okano H, Weng SM, Hsu CJ, Chang KH, Wu CC. Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation. Stem Cell Res. 2019 Jul 31;40:101524. doi: 10.1016/j.scr.2019.101524. [PubMed]

Abe Y, Ochiai D, Masuda H, Sato Y, Otani T, Fukutake M, Ikenoue S, Miyakoshi K, Okano H, Tanaka M. In Utero Amniotic Fluid Stem Cell Therapy Protects Against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion. Stem Cells Transl Med. 2019 Aug 13. doi: 10.1002/sctm.19-0002. [PubMed]

Morimoto S, Takahashi S, Fukushima K, Saya H, Suzuki N, Aoki M, Okano H, Nakahara J. Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis – Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial). Regen Ther. 2019 Jul 26;11:143-166. doi: 10.1016/j.reth.2019.07.002. eCollection 2019 Dec. [PubMed]

Tabata Y, Okano H. [Modeling Familial Parkinson’s Disease Using Patient-specific Induced Pluripotent Stem Cells].  Brain Nerve. 2019 Aug;71(8):875-883. doi: 10.11477/mf.1416201368. Japanese. [PubMed]

Huo BX, Zeater N, Lin MK, Takahashi YS, Hanada M, Nagashima J, Lee BC, Hata J, Zaheer A, Grünert U, Miller MI, Rosa MGP, Okano H, Martin PR, Mitra PP. Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets. Eur J Neurosci. 2019 Jul 25. doi: 10.1111/ejn.14529. [PubMed]

Hoshino Y, Nishide K, Nagoshi N, Shibata S, Moritoki N, Kojima K, Tsuji O, Matsumoto M, Kohyama J, Nakamura M, Okano H. The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury. Sci Rep. 2019 Jul 8;9(1):9844. doi: 10.1038/s41598-019-46069-z. [PubMed]

Li Y, Kanzaki S, Shibata S, Nakamura M, Ozaki M, Okano H, Ogawa K. Comparison of inner ear drug availbability of combined treatment with systemic or local drug injections alone. Neurosci Res. 2019 Jul 3. pii: S0168-0102(19)30250-0. doi: 10.1016/j.neures.2019.07.001. [PubMed]

Sone T, Shin M, Ouchi T, Sasanuma H, Miyamoto A, Ohte S, Tsukamoto S, Nakanishi M, Okano H, Katagiri T, Mitani K. Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation. Sci Rep. 2019 Jul 4;9(1):9705. doi: 10.1038/s41598-019-46105-y. [PubMed]

Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, Kitajima Y, Nishiyama A, Izumi R, Morimoto S, Okada Y, Kamei T, Nishida M, Nogami M, Kaneda S, Ikeuchi Y, Mitsuhashi H, Nakayama K, Fujii T, Warita H, Okano H, Aoki M. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons. EBioMedicine. 2019 Jun 28. pii: S2352-3964(19)30388-3. doi: 10.1016/j.ebiom.2019.06.013.9 [PubMed]

Nagoshi N, Tsuji O, Nakamura M, Okano H. Cell therapy for spinal cord injury using induced pluripotent stem cells. Regen Ther. 2019 Jun 13;11:75-80. doi: 10.1016/j.reth.2019.05.006. eCollection 2019 Dec. Review. [PubMed]

Kobayashi J, Hasegawa T, Sugeno N, Yoshida S, Akiyama T, Fujimori K, Hatakeyama H, Miki Y, Tomiyama A, Kawata Y, Fukuda M, Kawahata I, Yamakuni T, Ezura M, Kikuchi A, Baba T, Takeda A, Kanzaki M, Wakabayashi K, Okano H, Aoki M. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. FASEB J. 2019 Jun 18:fj201802051R. doi: 10.1096/fj.201802051R. [PubMed]

Kanda H, Shimamura R, Koizumi-Kitajima M, Okano H. Degradation of Extracellular Matrix by Matrix Metalloproteinase 2 Is Essential for the Establishment of the Blood-Brain Barrier in Drosophila. iScience. 2019 May 27;16:218-229. doi: 10.1016/j.isci.2019.05.027. [PubMed]

Nakajima M, Yoshimatsu S, Sato T, Nakamura M, Okahara J, Sasaki E, Shiozawa S, Okano H. Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming. Biochem Biophys Res Commun. 2019 Jun 6. pii: S0006-291X(19)31093-9. doi: 10.1016/j.bbrc.2019.05.175. [PubMed]

Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI. Tau isoform expression and phosphorylation in marmoset brains. J Biol Chem. 2019 Jun 5. pii: jbc.RA119.008415. doi: 10.1074/jbc.RA119.008415. [PubMed]

Kuzumaki N, Suda Y, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H, Narita M. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease. Brain. 2019 Jun 1;142(6):1675-1689. doi: 10.1093/brain/awz084. [PubMed]

Shibata S, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H. Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy. Front Neural Circuits. 2019 May 8;13:29. doi: 10.3389/fncir.2019.00029. [PubMed]

Kase Y, Otsu K, Shimazaki T, Okano H. Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. Stem Cell Reports. 2019 Apr 23. pii: S2213-6711(19)30132-8. doi: 10.1016/j.stemcr.2019.04.010. [PubMd]

Tamura R, Miyoshi H, Sampetrean O, Shinozaki M, Morimoto Y, Iwasawa C, Fukaya R, Mine Y, Masuda H, Maruyama T, Narita M, Saya H, Yoshida K, Okano H, Toda M. Visualization of spatiotemporal dynamics of human glioma stem cell invasion. Mol Brain. 2019 May 6;12(1):45. doi: 10.1186/s13041-019-0462-3. [PubMed]

Ito R, Nakae K, Hata J, Okano H, Ishii S. Semi-supervised deep learning of brain tissue segmentation. Neural Netw. 2019 Apr 1;116:25-34. doi: 10.1016/j.neunet.2019.03.014. [PubMed]

Hata J, Nakashima D, Tsuji O, Fujiyoshi K, Yasutake K, Sera Y, Komaki Y, Hikishima K, Nagura T, Matsumoto M, Okano H, Nakamura M. Noninvasive technique to evaluate the muscle fiber characteristics using q-space imaging. PLoS One. 2019 Apr 4;14(4):e0214805. doi: 10.1371/journal.pone.0214805. eCollection 2019. [PubMed]

Kojima K, Miyoshi H, Nagoshi N, Kohyama J, Itakura G, Kawabata S, Ozaki M, Iida T, Sugai K, Ito S, Fukuzawa R, Yasutake K, Renault-Mihara F, Shibata S, Matsumoto M, Nakamura M, Okano H. Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury. Stem Cells Transl Med. 2019 Mar;8(3):260-270. doi: 10.1002/sctm.18-0096. [PubMed]

Hata J, Endo K, Tsuji O, Arakawa S, Sato M, Yagi K, Fujiyoshi K, Okano H, Nakamura M. Analysis of skeletal-muscle condition after excessive loading of the lower legs by sequential magnetic resonance imaging. J Orthop Sci. 2019 Mar 13. pii: S0949-2658(19)30067-3. doi: 10.1016/j.jos.2019.01.016. [PubMed]

Abe Y, Komaki Y, Seki F, Shibata S, Okano H, Tanaka KF. Correlative study using structural MRI and super-resolution microscopy to detect structural alterations induced by long-term optogenetic stimulation of striatal medium spiny neurons. Neurochem Int. 2019 Feb 27. pii: S0197-0186(18)30450-9. doi: 10.1016/j.neuint.2019.02.017. [PubMed]

Kitamura K, Nagoshi N, Tsuji O, Matsumoto M, Okano H, Nakamura M. Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment. Int J Mol Sci. 2019 Feb 28;20(5). pii: E1054. doi: 10.3390/ijms20051054. Review. [PubMed]

Miller CT, Hale ME, Okano H, Okabe S, Mitra P. Comparative Principles for Next-Generation Neuroscience. Front Behav Neurosci. 2019 Feb 5;13:12. doi: 10.3389/fnbeh.2019.00012. eCollection 2019. [PubMed]

Muraoka N, Nara K, Tamura F, Kojima H, Yamakawa H, Sadahiro T, Miyamoto K, Isomi M, Haginiwa S, Tani H, Kurotsu S, Osakabe R, Torii S, Shimizu S, Okano H, Sugimoto Y, Fukuda K, Ieda M. Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming. Nat Commun. 2019 Feb 20;10(1):674. doi: 10.1038/s41467-019-08626-y. [PubMed]

Komatsu M, Kaneko T, Okano H, Ichinohe N. Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset. J Vis Exp. 2019 Feb 1;(144). doi: 10.3791/58980. [PubMed]

Iwasawa C, Tamura R, Sugiura Y, Suzuki S, Kuzumaki N, Narita M, Suematsu M, Nakamura M, Yoshida K, Toda M, Okano H, Miyoshi H. Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells. Int J Mol Sci. 2019 Feb 14;20(4). pii: E810. doi: 10.3390/ijms20040810. [PubMed]

Sadato N, Morita K, Kasai K, Fukushi T, Nakamura K, Nakazawa E, Okano H, Okabe S. Neuroethical Issues of the Brain/MINDS Project of Japan. Neuron. 2019 Feb 6;101(3):385-389. doi: 10.1016/j.neuron.2019.01.006. [PubMed]

Yoshimatsu S, Okahara J, Sone T, Takeda Y, Nakamura M, Sasaki E, Kishi N, Shiozawa S, Okano H. Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system. Sci Rep. 2019 Feb 6;9(1):1528. doi: 10.1038/s41598-018-37990-w. [PubMed]

Haga Y, Hata J, Uematsu A, Seki F, Komaki Y, Mizumura M, Nishio M, Kaneko T, Kishi N, Okano H, Furukawa A. MR Imaging Properties of ex vivo Common Marmoset Brain after Formaldehyde Fixation. Magn Reson Med Sci. 2019 Feb 7. doi: 10.2463/mrms.mp.2018-0086. [PubMed]

Nishihara K, Shiga T, Nakamura E, Akiyama T, Sasaki T, Suzuki S, Ko MSH, Tada N, Okano H, Akamatsu W. Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Stem Cell Reports. 2019 Jan 21. pii: S2213-6711(19)30001-3. doi: 10.1016/j.stemcr.2018.12.018. [PubMed]

Iwasawa C, Kuzumaki N, Suda Y, Kagawa R, Oka Y, Hattori N, Okano H, Narita M. Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations. Mol Brain. 2019 Jan 18;12(1):5. doi: 10.1186/s13041-019-0426-7.[PubMed]