2016年

Yamazaki K, Fukushima K, Sugawara M, Tabata Y, Imaizumi Y, Ishihara Y, Ito M, Tsukahara K, Kohyama J, Okano HFunctional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Different Oxygen and Medium Conditions. J Biomol Screen. 2016 Dec;21(10):1054-1064. doi: 10.1177/1087057116661291. [PubMed]

Okuno H, Nakabayashi K, Abe K, Ando T, Sanosaka T, Kohyama J, Akamatsu W, Ohyama M, Takahashi T, Kosaki K, Okano H. Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome. Congenit Anom (Kyoto). 2016 Dec 21. doi: 10.1111/cga.12206. [Epub ahead of print] [PubMed]

Ohta S, Yaguchi T, Okuno H, Chneiweiss H, Kawakami Y, Okano H. CHD7 promotes proliferation of neural stem cells mediated by MIF. Mol Brain. 2016 Dec 13;9(1):96. [PubMed]

Hoashi Y, Okamoto S, Abe Y, Matsumoto T, Tanaka J, Yoshida Y, Imaizumi K, Mishima K, Akamatsu W, Okano H, Baba K. Generation of neural cells using iPSCs from sleep bruxism patients with 5-HT2A polymorphism. J Prosthodont Res. 2016 Dec 1. pii: S1883-1958(16)30106-2. doi: 10.1016/j.jpor.2016.11.003. [Epub ahead of print] [PubMed]

Komaki Y, Hikishima K, Shibata S, Konomi T, Seki F, Yamada M, Miyasaka N, Fujiyoshi K, Okano HJ, Nakamura M, Okano H. Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia. Sci Rep2016 Nov 29;6:37802. doi: 10.1038/srep37802. [PubMed]

Sato Y, Mabuchi Y, Miyamoto K, Araki D, Niibe K, Houlihan DD, Morikawa S, Nakagawa T, Nakajima T, Akazawa C, Hori S, Okano H, Matsuzaki Y. Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc Expression. PLoS One2016 Nov 17;11(11):e0165946. doi: 10.1371/journal.pone.0165946. [PubMed]

Okano H, Sasaki E, Yamamori T, Iriki A, Shimogori T, Yamaguchi Y, Kasai K, Miyawaki A. Brain/MINDS: A Japanese National Brain Project for Marmoset Neuroscience. Neuron. 2016 Nov 2;92(3):582-590. doi: 10.1016/j.neuron.2016.10.018. [PubMed]

Yoshida K, Mimura Y, Ishihara R, Nishida H, Komaki Y, Minakuchi T, Tsurugizawa T, Mimura M, Okano H, Tanaka KF, Takata N. Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe. J Neurosci Methods. 2016 Oct 1. pii: S0165-0270(16)30222-9. doi: 10.1016/j.jneumeth.2016.09.013. [PubMed]

Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, F Tanaka K. Astrocyte-mediated infantile-onset leukoencephalopathy mouse model. Glia. 2016 Oct 17. doi: 10.1002/glia.23084. [PubMed]

Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Hattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W, Okano H. Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines. Mol Brain. 2016 Oct 3;9(1):88. [PubMed]

Okubo T, Iwanami A, Kohyama J, Itakura G, Kawabata S, Nishiyama Y, Sugai K, Ozaki M, Iida T, Matsubayashi K, Matsumoto M, Nakamura M, Okano H. Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury. Stem Cell Reports. 2016 Sep 15. pii: S2213-6711(16)30182-5. doi: 10.1016/j.stemcr.2016.08.015. [Epub ahead of print][PubMed]

Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H. Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016 Sep 22;6:33861. doi: 10.1038/srep33861. [PubMed]

Nakajima R, Okano H, Noce T. JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis. PLoS One. 2016 Sep 20;11(9):e0163466. doi: 10.1371/journal.pone.0163466. eCollection 2016. [PubMed]

Sugai K, Fukuzawa R, Shofuda T, Fukusumi H, Kawabata S, Nishiyama Y, Higuchi Y, Kawai K, Isoda M, Kanematsu D, Hashimoto-Tamaoki T, Kohyama J, Iwanami A, Suemizu H, Ikeda E, Matsumoto M, Kanemura Y, Nakamura M, Okano H. Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases. Mol Brain. 2016 Sep 19;9(1):85. doi: 10.1186/s13041-016-0265-8. [PubMed]

Cheung LY, Okano H, Camper SA. Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes. Mol Cell Endocrinol. 2016 Sep 8. pii: S0303-7207(16)30370-7. doi: 10.1016/j.mce.2016.09.005. [Epub ahead of print] [PubMed]

Grillner S, Ip N, Koch C, Koroshetz W, Okano H, Polachek M, Poo MM, Sejnowski TJ. Worldwide initiatives to advance brain research. Nat Neurosci. 2016 Aug 26;19(9):1118-22. doi: 10.1038/nn.4371. [PubMed]

Yamazaki Y, Hikishima K, Saiki M, Inada M, Sasaki E, Lemon RN, Price CJ, Okano H, Iriki A. Neural changes in the primate brain correlated with the evolution of complex motor skills. Sci Rep. 2016 Aug 8;6:31084. doi: 10.1038/srep31084. [PubMed]

Shinozaki M, Iwanami A, Fujiyoshi K, Tashiro S, Kitamura K, Shibata S, Fujita H, Nakamura M, Okano H. Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats. Neurosci Res. 2016 Aug 4. pii: S0168-0102(16)30108-0. doi: 10.1016/j.neures.2016.07.005. [Epub ahead of print] [PubMed]

Tashiro S, Nishimura S, Iwai H, Sugai K, Zhang L, Shinozaki M, Iwanami A, Toyama Y, Liu M, Okano H, Nakamura M. Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury. Sci Rep. 2016 Aug 3;6:30898. doi: 10.1038/srep30898. [PubMed]

Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y. Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors. BMC Cancer. 2016 Jul 27;16:548. doi: 10.1186/s12885-016-2416-9. [PubMed]

Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H. In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations. Mol Brain. 2016 Jul 19;9(1):70. doi: 10.1186/s13041-016-0246-y. [PubMed]

Hosoya M, Fujioka M, Okano H, Ogawa K. Distinct Expression Pattern of a Deafness Gene, KIAA1199, in a Primate Cochlea. Biomed Res Int. 2016;2016:1781894. doi: 10.1155/2016/1781894. Epub 2016 Jun 14. [PubMed]

Sato K, Oiwa R, Kumita W, Henry R, Sakuma T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara N, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Hata JI, Okano H, Sasaki E. Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing. Cell Stem Cell. 2016 Jun 29. pii: S1934-5909(16)30153-9. doi: 10.1016/j.stem.2016.06.003. [Epub ahead of print] 【PubMed】

Suzuki N, Hosoya M, Oishi N, Okano H, Fujioka M, Ogawa K. Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea.  Neuroreport. 2016 Jun 23. [Epub ahead of print]PMID :27341211 PubMed

Hara Y, Motoi Y, Hikishima K, Mizum H, Onoe H, Matsumoto SE, Elahi M, Okano H, Aoki S, Hattori N.  Involvement of the septo-hippocampal cholinergic pathway in association with septal acetylcholinesterase upregulation in a mouse model of tauopathy.  Curr Alzheimer Res. 2016 Jun 2. [Epub ahead of print]  PMID:   27335039 PubMed

 Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek MA, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T.   Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 Jun 6. doi: 10.1038/nature17988. [Epub ahead of print] PMID: 27281208PubMed

Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami KI, Tanaka M, Fukuda K.  H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.  Stem Cell Reports. 2016 May 20. pii: S2213-6711(16)30040-6. doi: 10.1016/j.stemcr.2016.04.015. [Epub ahead of print]  PMID: 27237376 PubMed

Fukusumi H, Shofuda T, Bamba Y, Yamamoto A, Kanematsu D, Handa Y, Okita K, Nakamura M, Yamanaka S, Okano H, Kanemura Y. Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins. Stem Cells Int. 2016;2016:7235757. doi: 10.1155/2016/7235757. Epub 2016 Apr 26. PMID: 27212953 PubMed

Narumi S, Amano N, Ishii T, Katsumata N, Muroya K, Adachi M, Toyoshima K, Tanaka Y, Fukuzawa R, Miyako K, Kinjo S, Ohga S, Ihara K, Inoue H, Kinjo T, Hara T, Kohno M, Yamada S, Urano H, Kitagawa Y, Tsugawa K, Higa A, Miyawaki M, Okutani T, Kizaki Z, Hamada H, Kihara M, Shiga K, Yamaguchi T, Kenmochi M, Kitajima H, Fukami M, Shimizu A, Kudoh J, Shibata S, Okano H, Miyake N, Matsumoto N, Hasegawa T. SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7. Nat Genet. 2016 May 16. doi: 10.1038/ng.3569. [Epub ahead of print] PMID: 27182967 PubMed

Ouchi T, Morikawa S, Shibata S, Fukuda K, Okuno H, Fujimura T, Kuroda T, Ohyama M, Akamatsu W, Nakagawa T, Okano H.  LNGFR+THY-1+ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells.  Differentiation. 2016 May 10. pii: S0301-4681(15)30062-1. doi:10.1016/j.diff.2016.04.003. [Epub ahead of print] PMID:  27178356 PubMed

Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H, Miura K. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.  Nat Commun. 2016 May 10;7:11471. doi: 10.1038/ncomms11471. PMID:27161380PubMed

Bertolin AP, Katz MJ, Yano M, Pozzi B, Acevedo JM, Blanco-Obregón D, Gándara L, Sorianello E, Kanda H, Okano H, Srebrow A, Wappner P. Musashi mediates translational repression of the Drosophila hypoxia inducible factor. Nucleic Acids Res. 2016 May 3. pii: gkw372. [Epub ahead of print]PMID:27141964PubMed

Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion. PLoS One. 2016 Apr 21;11(4):e0153957. doi: 10.1371/journal.pone.0153957. eCollection 2016.PMID: 27099926 PubMed

Hosoya M, Fujioka M, Kobayashi R, Okano H, Ogawa K. Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation. Neurosci Res. 2016 Apr 18. pii: S0168-0102(16)30006-2. doi: 10.1016/j.neures.2016.04.002. [Epub ahead of print] PMID: 27091614 PubMed

Isoda M, Kohyama J, Iwanami A, Sanosaka T, Sugai K, Yamaguchi R, Matsumoto T, Nakamura M, Okano H. Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions. Neurosci Res. 2016 Apr 12. pii: S0168-0102(16)30007-4. doi: 10.1016/j.neures.2016.04.003. [Epub ahead of print] PMID: 27083781 PubMed

Andoh-Noda T, Inouye MO, Miyake K, Kubota T, Okano H, Akamatsu W. Modeling Rett syndrome using human induced pluripotent stem cells. CNS Neurol Disord Drug Targets. 2016 Apr 13. [Epub ahead of print] PMID: 27071793 PubMed

Morikawa S, Ouchi T, Shibata S, Fujimura T, Kawana H, Okano H, Nakagawa T.  Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research.  Stem Cells Int. 2016;2016:2849879. doi: 10.1155/2016/2849879. Epub 2016 Feb 24. Review.  PMID:  27006661 PubMed

Ichiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H. Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2016 Mar 16. pii: S2213-6711(16)00062-X. doi: 10.1016/j.stemcr.2016.02.011. [Epub ahead of print] PMID:26997647 PubMed

Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K, Toda M. MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53.  Cancer Res. 2016 Mar 15. pii: canres.1011.2015. [Epub ahead of print] PMID: 26980763  PubMed

Fujimura T, Shibata S, Shimojima N, Morikawa Y, Okano H, Kuroda T. Fluorescence Visualization of the Enteric Nervous Network in a Chemically Induced Aganglionosis Model. PLoS One. 2016 Mar 4;11(3):e0150579. doi: 10.1371/journal.pone.0150579. eCollection 2016. PMID:26,943,905 PubMed

Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H. Application of q-Space Diffusion MRI for the Visualization of White Matter. J Neurosci. 2016 Mar 2;36(9):2796-808. doi: 10.1523/JNEUROSCI.1770-15.2016. PMID: 26937016 PubMed

Hosoya M, Fujioka M, Ogawa K, Okano H. Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.  Sci Rep. 2016 Feb 26;6:22250. doi: 10.1038/srep22250. PMID: 26915689PubMed

Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H. Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling.  Stem Cell Reports. 2016 Feb 9. pii: S2213-6711(16)00027-8. doi: 10.1016/j.stemcr.2016.01.010. [Epub ahead of print] PMID: 26905201 PubMed

Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T. Erratum: Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism. Sci Rep. 2016 Jan 29;6:20268. doi: 10.1038/srep20268. No abstract available. PMID:26822806PubMed

Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S. MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.Elife. 2016 Jan 26;5. pii: e09394. doi: 10.7554/eLife.09394.PMID:26809474PubMed

Nishiyama Y, Iwanami A, Kohyama J, Itakura G, Kawabata S, Sugai K, Nishimura S, Kashiwagi R, Yasutake K, Isoda M, Matsumoto M, Nakamura M, Okano H. Safe and efficient method for cryopreservation of human induced pluripotent stem cell-derived neural stem and progenitor cells by a programmed freezer with a magnetic field. Neurosci Res. 2016 Jan 21. pii: S0168-0102(15)00296-5. doi: 10.1016/j.neures.2015.11.011. [Epub ahead of print]PMID:26804710PubMed

Yano M, Hayakawa-Yano Y, Okano H. RNA Regulation went wrong in neurodevelopmental disorders: the example of Msi/Elav RNA binding proteins. Int J Dev Neurosci. 2016 Jan 12. pii: S0736-5748(15)30163-5. doi:10.1016/j.ijdevneu.2016.01.002. [Epub ahead of print] Review.PMID:26796049PubMed