Kspot is an ubiquitin ligase expressed in the nervous system. It induces ubiquitination of substrate molecules within neurons, leading to degradation by proteasomes. In addition, Kspot is considered to be a potential target antigen molecule for the paraneoplastic neurologic syndrome, an autoimmune disease.

Contents of Our Work

RNA-binding protein
• Functional analysis of Musashi expressed intensely in the neural stem cells
• Mechanisms for induction of neural differentiation by the Hu protein family
• Mechanism of mRNA transport and localization to/in neural processes by Hzf

Ubiquitin ligase
• Functional analysis of Kspot expressed specifically in the nervous system

Transcription factors
• Analysis of Sox21, a transcription factor highly expressed in the neural stem and precursor cells

Development of methods for the prevention and treatment of hearing loss
• Research towards regeneration of inner ear hair cells (jointly with the Department of Otorhinolaryngology, School of Medicine, Keio University

Contact

Hirotaka-James Okano?hjokano?sc.itc.keio.ac.jp?

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